期刊
CURRENT DRUG TARGETS
卷 13, 期 5, 页码 594-601出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945012800398955
关键词
Drug design; molecular imaging; neurodegeneration; nicotine; orthosteric ligand
Molecular imaging of brain structures by highly sensitive non-invasive techniques offers unique possibilities in the understanding of physiological and pathological processes in the central nervous system. In particular, the quantitative analysis by positron emission tomography (PET) of alpha 7 nicotinic acetylcholine receptors (alpha 7 nAChR), which are involved in different signalling pathways in the brain, is assumed to provide important information on the relation between receptor dysfunction and the pathogeneses of neuropsychiatric brain diseases, but the applicability of this imaging approach is still hampered due to insufficient imaging agents. This paper presents the recent efforts made to develop PET radiotracers targeting alpha 7 nAChR as well as the current state of the evaluation of the most promising radiolabelled compounds in animal models and humans.
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