期刊
CURRENT DRUG TARGETS
卷 13, 期 3, 页码 432-439出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945012799424615
关键词
Cancer; endosialin; fibroblast; inflammation; pericytes; stromal cells
资金
- Michael Smith Foundation for Health Research Biomedical Research / Crohns' and Colitis Foundation of Canada
- Canadian Institutes for Health Research (CIHR)
- Canada Foundations for Innovation
CD248, also known as endosialin or tumor endothelial marker-1 (TEM-1), is a C-type lectin-like domain (CTLD) containing cell surface glycoprotein that is expressed by stromal cells of proliferating tissues during embryogenesis and postnatally in tumors and inflammatory lesions. Loss-of-function studies in mice support the notion that CD248 promotes tumor growth and inflammation, observations that are stimulating interest in evaluating this molecule as a therapeutic target. In spite of these advances, the mechanisms by which CD248 modulates cancer and inflammation remain largely enigmatic. This review highlights our current understanding of CD248, its structure, pattern of expression, regulation and function in various disease processes.
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