期刊
CURRENT DRUG TARGETS
卷 13, 期 9, 页码 1138-1147出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945012802002393
关键词
Antimicrobial peptides; leishmaniasis; malaria; protozoa
资金
- European Union [HEALTH-2007-223414]
- Fondo de Investigaciones Sanitarias [RICET RD 06/0021/0006, PI09-01928, RD 06/0021/0010]
- MINECO [SAF2011-24899]
- Generalitat de Catalunya [SGR09-00492]
- Alianza Cuatro Universidades
- MICINN
Diseases caused by protozoan parasites can pose a severe thread to human health and are behind some serious neglected tropical diseases like malaria and leishmaniasis. Though several different drugs have been developed in order to eradicate these diseases, a successful candidate has not yet been discovered. Among the most active compounds tested, antimicrobial peptides (AMPs) are particularly appealing because of their wide spectrum of action. AMPs have been described to perturb protozoan homeostasis by disrupting the cellular membranes but also by interfering with key processes in the parasite metabolism. In this review we describe the diverse mechanisms of action of AMPs on protozoan targets and how they can be exploited to treat diseases. Moreover, we describe with detail the antimicrobial action of AMPs on two major parasitical infections: leishmaniasis and malaria. All the features reviewed here show that AMPs are promising drugs to target protozoan parasites and that further understanding of the mechanism of action of these compounds will lead to improved drugs that could be worth to test in a clinical phase.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据