期刊
CURRENT DRUG TARGETS
卷 13, 期 14, 页码 1689-1697出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945012804545452
关键词
Inflammation and cancer; inflammatory bowel disease; colorectal cancer; chemoprevention; animal model
资金
- Ministry of Health and Welfare of Japan
- Ministry of Education, Science, Sports and Culture of Japan [13671986, 23501324]
- Grants-in-Aid for Scientific Research [13671986, 23501324] Funding Source: KAKEN
Inflammation is a risk factor for cancer development in several tissues. In the colorectum, inflammatory bowel disease (ulcerative colitis and Crohn's disease) is a longstanding inflammatory disease with increased risk for colorectal cancer (CRC). Several molecular events involving in chronic inflammatory process contribute to multi-stage carcinogenesis of CRC in the inflamed colon. They include alterations in production of reactive oxygen and nitrogen species, up-regulation of pro-inflammatory cytokines and inflammatory enzymes, and intestinal immune system. In this short review, experimental animal models of inflammation-associated CRC are described. Also, some preclinical data on chemoprevention of inflammation-associated CRC by astaxanthin and a specific inhibitor of nitric oxide synthase using these inflammation-related -CRC models is briefly introduced.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据