期刊
CURRENT DRUG TARGETS
卷 12, 期 9, 页码 1303-1310出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945011796150316
关键词
Foxo; post-translational modifications; phosphorylation; acetylation; ubiquitination
资金
- United States Public Health Service [NS052325, NS060754, NS064232]
The Forkhead Box O (Foxo) proteins represent an evolutionarily conserved family of transcription factors that play an important role in regulating processes including metabolism, longevity, and cell death/survival. How is it that a single transcription factor can initiate such divergent cellular responses? We will review the evidence that specific patterns of post-translational modifications play a key role in directing Foxo into various transcriptional readouts. This regulation appears to take on a two tiered regulatory model; with a group of well defined post-translational modifications regulating nuclear localization and transcriptional activity while a second set of modifications regulate the transcriptional specificity of Foxo.
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