期刊
CURRENT DRUG TARGETS
卷 12, 期 3, 页码 288-301出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945011794815347
关键词
Phytochemicals; anti-inflammation; nuclear factor-kappa B; cyclooxygenase; lipoxygenase; phospholipase A2; tumor necrosis factor alpha
Inflammation is a natural response of living organisms to the presence of internal and external substances which are recognized by the host as being non-self or foreign invader. It is also a cascade leading to the healing of damaged tissue. Uncontrolled inflammation often results in chronic diseases such as arthritis, autoimmune disorder, cancer, dementia, diabetic, neurodegeneration and vascular disease. The list keeps growing due to the increasing number of identified molecular markers that are associated with inflammatory genes or transcription factors. Among various transcription factors, nuclear factor kappa B (NF-kappa B) is the master switch for proinflammatory genes and transactivates arachidonic acid pathway enzymes when activated. Through evolution, plants have developed vast classes of compounds to fight inflammation. Most of them belong to the chemical group of alkaloids, coumarins, flavonoids, polyphenols and terpenoids. This review article presents and discusses results obtained from literature search on recent findings in plant-derived compounds, which exhibit anti-inflammatory activity in rheumatoid arthritis, allergy and asthma via the suppression of the arachidonic acid pathway. IC(50)s of the compounds obtained from the literature are thus tabulated into six groups of inhibitors based on the enzyme target of phospholipase A2, cycloxygenase 1 and 2, 5-, 12- and 15-lipoxygenase. Modulation of Th1/Th2 cytokines and histamine/mucus release by some of these enzyme inhibitors are also briefly discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据