期刊
CURRENT DRUG TARGETS
卷 10, 期 2, 页码 118-125出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945009787354601
关键词
Prostate specific membrane antigen; prostate cancer; immunotherapy; drug targeting; radiotherapy; gene therapy
Prostate cancer is the most common cancer in men from Western industrialized countries and a significant proportion of patients progress to advanced metastatic disease, for which currently no curative treatment exists. Therefore, new therapeutic approaches need to be considered. Prostate specific membrane antigen (PSMA) is an integral, non-shed type 2 membrane protein that is highly and specifically expressed on prostate epithelial cells and strongly upregulated in prostate cancer. PSMA is also present in the neovasculature of other solid tumors. These findings have spurred the development of PSMA-targeted therapies and first-generation products have entered clinical testing. The proposed strategies range from targeted toxins and radionuclides to immunotherapeutic agents. The present review provides an overview of these approaches.
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