期刊
CURRENT DRUG TARGETS
卷 9, 期 7, 页码 532-547出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945008784911787
关键词
Wnt; beta-catenin; signaling; dysregulation; cancer; therapy
资金
- BBSRC [BB/D00117X/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D00117X/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/D00117X/1] Funding Source: Medline
There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches and discusses potential opportunities for intervention at multiple levels within the Wnt pathway.
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