期刊
CURRENT DRUG METABOLISM
卷 14, 期 5, 页码 547-564出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389200211314050005
关键词
Nanotechnologies; nanoparticles; gene therapy; anticancer drugs; drug carriers; cancer; cytostatic; targeted therapy
资金
- Grant Agency of the Czech Republic [GACR 102/11/1068]
- project CEITEC - Central European Institute of Technology from European Regional Development Fund [CZ.1.05/1.1.00/02.0068]
- project for conceptual development of research organization [00064203]
This review provides a brief overview of the variety of carriers employed for targeted drug delivery used in cancer therapy and summarizes advantages and disadvantages of each approach. Particularly, the attention was paid to polymeric nanocarriers, liposomes, micelles, polyethylene glycol, poly(lactic-co-glycolic acid), dendrimers, gold and magnetic nanoparticles, quantum dots, silica nanoparticles, and carbon nanotubes. Further, this paper briefly focuses on several anticancer agents (paclitaxel, docetaxel, camptothecin, doxorubicin, daunorubicin, cisplatin, curcumin, and geldanamycin) and on the influence of their combination with nanoparticulate transporters to their properties such as cytotoxicity, short life time and/or solubility.
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