期刊
CURRENT DRUG METABOLISM
卷 13, 期 5, 页码 615-623出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389200211209050615
关键词
UDP-glucuronosyltransferase; herbal medicines; glucuronidation; herb-drug interaction
资金
- National Science & Technology Major Project of China Key New Drug Creation and Manufacturing Program [2012ZX09506001-004, 2009ZX09304-003]
- National Natural Science Foundation of China [81173120]
UDP-glucuronosyltransferases (UGTs) play important roles in the disposition of many drugs and xenobiotics. Herbal medicine, an important group of multicomponent therapeutics, is widely and increasingly used. Drug metabolism of herbal medicine mediated by cytochrome P450s has been extensively studied; however, herbal medicine metabolism mediated by UGTs has not been adequately investigated. Thus, it is necessary to evaluate current evidence on the glucuronidation of herbal medicines by UGTs. In this review, the research advances of the potential for commonly used herbal medicines as UGT substrate and modulator are summarized. In addition, the herb-drug interactions associated with UGTs are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据