期刊
CURRENT DRUG METABOLISM
卷 10, 期 8, 页码 842-850出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920009790274586
关键词
Dendrimer; doxorubicin; liposome; pharmacokinetic; nanomedicine; poly(ethylene glycol)
资金
- National Science Council of the Republic of China, Taiwan [NSC-96-2221-E-033-049, NSC-97-2218-E-033-001]
- Chung Yuan Christian University [CYCU-98-CR-BE]
The efficacy of drug delivery systems using nanoparticles to enhance the pharmacokinetic properties of drugs has been confirmed in both preclinical trials and clinical settings. A nanosized drug system has improved efficacy, reduced side effects and clearance, increased cellular uptake and prolonged time in circulation. This article will focus recent studies of the pharmacokinetic behavior of such systems as poly(ethylene glycol) and polyamidoamine. Their derivatives are also analyzed. Additionally, some diseases with very good responsiveness are aslo reported.
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