期刊
CURRENT DIABETES REPORTS
卷 12, 期 5, 页码 517-523出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11892-012-0308-1
关键词
Stem cell educator therapy; Immune balance; Immune modulation; Cord blood-derived multipotent stem cells; Mesenchymal stem cells; Hematopoietic stem cells; Autoimmune regulator (Aire); Type 1 diabetes
资金
- Juvenile Diabetes Research Foundation International
- American Diabetes Association
- China Jinan 5150 Program for Oversea Scholar
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that causes the deficit of pancreatic islet beta cells. A true cure has proven elusive despite intensive research pressure by using conventional approaches over the past 25 years. The situation highlights the challenges we face in conquering this disease. Alternative approaches are needed. Increasing evidence demonstrates that stem cells possess the function of immune modulation. We established the Stem Cell Educator therapy by using cord blood-derived multipotent stem cells (CB-SCs). A closed-loop system that circulates a patient's blood through a blood cell separator, briefly co-cultures the patient's lymphocytes with adherent CB-SCs in vitro, and returns the educated lymphocytes (but not the CB-SCs) to the patient's circulation. Our clinical trial reveals that a single treatment with the Stem Cell Educator provides lasting reversal of autoimmunity that allows regeneration of islet beta cells and improvement of metabolic control in subjects with long-standing T1D.
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