期刊
CURRENT CANCER DRUG TARGETS
卷 11, 期 2, 页码 156-163出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156800911794328411
关键词
Silica; nanoparticles; drug/gene delivery; nano-probes; targeting
类别
资金
- National Natural Science Foundation of China [30700151, 81071257]
- New Century Excellent Talents Program in Chinese Universities [NCET-09-0263]
- Sichuan Youth Science and Technology Foundation of China [2010JQ0004]
- Visiting Scholar Foundation of Key Lab of Biorheological Science and Technology in Chongqing University
- University of Electronic Science and Technology of China [Y02018023601062]
The application of nanotechnology to biomedical research is expected to have a major impact leading to the development of new types of diagnostic and therapeutic tools. One focus in nanobiotechnology is to develop safe and efficient drug/gene delivery vehicles. Research into the rational delivery and targeting of pharmaceutical, therapeutic and diagnostic agents is at the forefront of projects in nanomedicine. Silica, as a major and natural component of sand and glass, is a versatile material due to the variety of available chemical and physical modifications that are available, and recently have been widely applied in nanobiotechnology as drug/gene carriers or fluorescent nano-probes. The goal of this brief review is to illustrate selected examples of various functionalized silica nanoparticles as drug/gene delivery systems that have been applied to the arenas of human disease therapy or detection (molecular and cellular imaging).
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