Nutritional State Modulates the Neural Processing of Visual Motion

Food deprivation alters the processing of sensory information, increasing neural activity in the olfactory and gustatory systems in animals across phyla [1-4]. Neural signaling is metabolically costly [5-9], and a hungry animal has limited energy reserves, so we hypothesized that neural activity in other systems may be downregulated by food deprivation. We investigated this hypothesis in the motion vision pathway of the blowfly. Like other animals [10-17], flies augment their motion vision when moving: they increase the resting activity and gain of visual interneurons supporting the control of locomotion and gaze [18-21]. In the present study, walking-induced changes in visual processing depended on the nutritional state-they decreased with food deprivation and recovered after subsequent feeding. We found that changes in the motion vision pathway depended on walking speed in a manner dependent on the nutritional state. Walking also reduced response latencies in visual interneurons, an effect not altered by food deprivation. Finally, the optomotor reflex that compensates for visual wide-field motion was reduced in food-deprived flies. Thus, walking augmented motion vision, but the effect was decreased when energy reserves were low. Our results suggest that energy limitations may drive the rebalancing of neural activity with changes in the nutritional state.