期刊
CURRENT BIOLOGY
卷 23, 期 17, 页码 R812-R816出版社
CELL PRESS
DOI: 10.1016/j.cub.2013.06.047
关键词
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资金
- National Sciences Foundation Synthetic Biology Engineering Research Center (NSF SynBERC)
- National Institutes of Health (NIH)
- Wyss Institute for Biologically Inspired Engineering
- Defense Advanced Research Projects Agency
Cellular memory - conversion of a transient signal into a sustained response - is a common feature of biological systems. Synthetic biologists aim to understand and re-engineer such systems in a reliable and predictable manner. Synthetic memory circuits have been designed and built in vitro and in vivo based on diverse mechanisms, such as oligonucleotide hybridization, recombination, transcription, phosphorylation, and RNA editing. Thus far, building these circuits has helped us explore the basic principles required for stable memory and ask novel biological questions. Here we discuss strategies for building synthetic memory circuits, their use as research tools, and future applications of these devices in medicine and industry.
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