期刊
CURRENT BIOLOGY
卷 22, 期 7, 页码 601-607出版社
CELL PRESS
DOI: 10.1016/j.cub.2012.01.063
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Uehara Memorial Foundation
- Mitsubishi Foundation
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [21370103, 22700428, 20247030, 10J09017, 22370075, 22127001, 22870008, 10J07483, 21370098, 22657055, 24657147, 22570218, 23241058, 22127002, 21570219, 11J05881] Funding Source: KAKEN
Teleosts have an asymmetrical caudal fin skeleton formed by the upward bending of the caudal-most portion of the body axis, the ural region [1-3]. This homocercal type of caudal fin ensures powerful and complex locomotion and is regarded as one of the most important innovations for teleosts during adaptive radiation in an aquatic environment [4-6]. However, the mechanisms that create asymmetric caudal fin remain largely unknown. The spontaneous medaka (teleost fish) mutant, Double anal fin (Da), exhibits a unique symmetrical caudal skeleton that resembles the diphycercal type seen in Polypterus and Coelacanth. We performed a detailed analysis of the Da mutant to obtain molecular insight into caudal fin morphogenesis. We first demonstrate that a large transposon, inserted into the enhancer region of the zic1 and zic4 genes (zic1/zic4) in Da, is associated with the mesoderm-specific loss of their transcription. We then show that zic1/zic4 are strongly expressed in the dorsal part of the ural mesenchyme and thereby induce asymmetric caudal fin development in wild-type embryos, whereas their expression is lost in Da. Comparative analysis further indicates that the dorsal mesoderm expression of zic1/zic4 is conserved in teleosts, highlighting the crucial role of zic1/zic4 in caudal fin morphogenesis.
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