期刊
CURRENT BIOLOGY
卷 22, 期 15, 页码 1403-1409出版社
CELL PRESS
DOI: 10.1016/j.cub.2012.05.033
关键词
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资金
- Graduate Program in Biological Sciences at Vanderbilt University
- National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [NIAID: F31AI091343-01]
- Searle Scholars Program
- National Science Foundation [DEB-0844968]
The domestication of animals, plants, and microbes fundamentally transformed the lifestyle and demography of the human species [1]. Although the genetic and functional underpinnings of animal and plant domestication are well understood, little is known about microbe domestication [2-6]. Here, we systematically examined genome-wide sequence and functional variation between the domesticated fungus Aspergillus oryzae, whose saccharification abilities humans have harnessed for thousands of years to produce sake, soy sauce, and miso from starch-rich grains, and its wild relative A. flavus, a potentially toxigenic plant and animal pathogen [7]. We discovered dramatic changes in the sequence variation and abundance profiles of genes and wholesale primary and secondary metabolic pathways between domesticated and wild relative isolates during growth on rice. Our data suggest that, through selection by humans, an atoxigenic lineage of A. flavus gradually evolved into a cell factory for enzymes and metabolites involved in the saccharification process. These results suggest that whereas animal and plant domestication was largely driven by Neolithic genetic tinkering of developmental pathways, microbe domestication was driven by extensive remodeling of metabolism.
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