期刊
CURRENT BIOLOGY
卷 22, 期 18, 页码 1699-1704出版社
CELL PRESS
DOI: 10.1016/j.cub.2012.07.005
关键词
-
资金
- Federation of European Biochemical Societies
- University of Oxford Glasstone Research Fellowship
- Biotechnology and Biological Sciences Research Council Career Development Fellowship [BB/G023905/1, BB/F012934/1]
- European Molecular Biology Organization Young Investigator Programme
- Royal Society Wolfson Merit Award
- Max Planck Society core grant
- European Commission (FP7-ITN SIREN) [214788-2]
- Human Frontier Science Program [RGP0047/2010]
- BBSRC [BB/G023905/1, BB/F012934/1] Funding Source: UKRI
- EPSRC [EP/I017909/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F012934/1, BB/G023905/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/I017909/1] Funding Source: researchfish
The hormone cytokinin (CK) controls root length in Arabidopsis thaliana by defining where dividing cells, derived from stem cells of the root meristem, start to differentiate [1-6]. However, the regulatory inputs directing CK to promote differentiation remain poorly understood. Here, we show that the HD-ZIPIII transcription factor PHABULOSA (PHB) directly activates the CK biosynthesis gene ISOPENTENYL TRANSFERASE 7 (IPT7), thus promoting cell differentiation and regulating root length. We further demonstrate that CK feeds back to repress both PHB and microRNA165, a negative regulator of PHB. These interactions comprise an incoherent regulatory loop in which CK represses both its activator and a repressor of its activator. We propose that this regulatory circuit determines the balance of cell division and differentiation during root development and may provide robustness against CK fluctuations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据