期刊
CURRENT BIOLOGY
卷 19, 期 21, 页码 1827-1832出版社
CELL PRESS
DOI: 10.1016/j.cub.2009.08.052
关键词
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资金
- National Institute of General Medical Science [1R01GM081451-01]
- National Natural Science Foundation of China [90817105]
Cortical microtubulles (MTs) participate in the spatial control of cell expansion and division that is required for plant growth and morphogenesis. Well-ordered transverse cortical MTs; promote cell elongation and restrict radial cell expansion [1, 2]. The molecular mechanism controlling their ordering is poorly understood. We report the first known signaling pathway that promotes the organization of cortical MTs; into parallel arrays oriented perpendicular to the axis of cell elongation in plants. Well-ordered MTs locally restrict cell expansion to promote indentation formation in the jigsaw-puzzle-shaped pavement cells of Arabidopsis leaves [3, 4]. Deleting ROP6, a Rho-family GTPase, randomized cortical MTs and released the localized restriction of cell expansion, whereas ROP6 overexpression-enhanced MT ordering, turning the jigsaw-puzzle appearance of cells into a cylindrical shape. ROP6 directly binds and activates MT-associated RIC1 to achieve the MT ordering. The ROP6-RIC1 pathway also affects MT ordering of hypocotyl cells, showing a broad role for this pathway in the spatial regulation of cell expansion.
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