期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 281, 期 -, 页码 51-60出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2015.03.008
关键词
Treg; GITR; PD-1; STAT-5; Vitamin D; LOMG
资金
- TUBITAK [110S297]
- BMBF [01DL12027]
- Istanbul University Research Fund (UDP)
- Istanbul University Research Fund (BYP)
Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4(+)CD25(++) (Treg) and responder T cells (Tresp, CD4(+)CD25(-)) were observed in LOMG patients. GITR was decreased on CD4(+)CD25(++) of all patients. Decrease of FOXP3 was associated with lower phosphorylation of STAT5.1,25-dihydroxyvitamin D3 (VitD3) increased suppression in co-culture with a stronger effect in patients by acting possibly both on cell groups. Changes in surface molecules and intracellular pathways contribute to the defects of Treg in non-thymomatous AChR-MG and VitD3 can have modulatory effects. (C) 2015 Elsevier B.V. All rights reserved.
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