期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 284, 期 -, 页码 18-29出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2015.05.003
关键词
Th1 differentiation; TCR signalling; T-cell activation; Dopamine receptors; Knockout mice; Neuroimmunology
资金
- Fondo Nacional de Desarrollo Cientifico y Tecnologico de Chile (FONDECYT) [1130271]
- Comision Nacional de Investigacion Cientifica y Tecnologica de Chile (CONICYT) [PFB-16]
- Michael J. Fox Foundation [10332]
- Universidad Andres Bello
Dopamine receptors have been described in T-cells, however their signalling pathways coupled remain unknown. Since cAMP and ERKs play key roles regulating T-cell physiology, we aim to determine whether cAMP and ERK1/2-phosphorylation are modulated by dopamine receptor 3 (D3R) and D5R, and how this modulation affects CD4(+) T-cell activation and differentiation. Our pharmacologic and genetic evidence shows that D3R-stimulation reduced CAMP levels and ERK2-phosphorylation, consequently increasing CD4(+) T-cell activation and Th1-differentiation, respectively. Moreover, D5R expression reinforced TCR-triggered ERK1/2-phosphorylation and T-cell activation. In conclusion, these findings demonstrate how D3R and D5R modulate key signalling pathways affecting CD4(+) T-cell activation and Th1-differentiation. (C) 2015 Elsevier B.V. All rights reserved.
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