4.4 Article

Oxidized PLs and Vascular Inflammation

期刊

CURRENT ATHEROSCLEROSIS REPORTS
卷 15, 期 5, 页码 -

出版社

CURRENT MEDICINE GROUP
DOI: 10.1007/s11883-013-0323-y

关键词

Oxidized PL; Vascular inflammation; Atherosclerosis; Lipoxygenase

资金

  1. British Heart Foundation [RG/12/11/29815] Funding Source: Medline
  2. British Heart Foundation [RG/12/11/29815] Funding Source: researchfish

向作者/读者索取更多资源

Oxidized PLs (OxPLs) generated in health and disease are now recognized as important mediators of cellular signalling. There is an increasing body of evidence showing that PL peroxidation is not only increased in vascular disorders, but is also a physiological event of relevance to coagulation, innate immunity, and self-tolerance. Nonenzymatically formed OxPLs generated during chronic inflammation is an uncontrolled event, generating hundreds of diverse structures, and prone to more deleterious bioactivities. In contrast, enzymatic formation of OxPLs is tightly regulated, involving receptors and intracellular signaling, acting as part of the normal physiological response to injury in order to restore homeostasis. In the present review, the major nonenzymatic OxPLs structures found during vascular inflammation are summarized, along with a brief description of their known biological activities. Also, we review what is currently known about enzymatic formation of OxPLs by acutely activated immune cells and their signaling actions under homeostatic and pathological conditions.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据