期刊
CURRENT ATHEROSCLEROSIS REPORTS
卷 15, 期 9, 页码 -出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11883-013-0353-5
关键词
Biomarker; Calibration; Cardiovascular disease; Epidemiology; Nutrition; Measurement error
资金
- NCI NIH HHS [R01 CA119171, P01 CA053996] Funding Source: Medline
- NIGMS NIH HHS [R01 GM106177] Funding Source: Medline
- WHI NIH HHS [N01WH22110] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P01CA053996, R01CA119171] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM106177] Funding Source: NIH RePORTER
- WOMEN&apos
- S HEALTH INITIATIVE - OFFICE OF THE DIRECTOR NIH [N01WH022110] Funding Source: NIH RePORTER
Reports from nutritional epidemiology studies lack reliability if based solely on self-reported dietary consumption estimates. Consumption biomarkers are available for some components of diet. These can be collected in subsets of study cohorts, along with corresponding self-report assessments. Linear regression of (log-transformed) biomarker values on corresponding self-report values and other pertinent study subject characteristics yields calibration equations for dietary consumption, from which calibrated consumption estimates can be calculated throughout study cohorts. Nutritional epidemiology disease association studies of enhanced reliability can be expected from analyses that relate disease risk to calibrated consumption estimates. Applications to the study of energy and protein consumption in relation to cardiovascular diseases, type 2 diabetes, and cancer in the Women's Health Initiative will be briefly summarized. Also, challenges related to variables that may either mediate or confound associations of interest will be described, along with the need for longitudinal biomarker and self-report data, and the need for additional nutritional biomarker development.
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