期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 278, 期 -, 页码 144-158出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2014.12.013
关键词
Inflammation; Astrocyte; Microglia; Brain; Fever
资金
- NICHD
- Japan Society for the Promotion of Science [24500411]
- Grants-in-Aid for Scientific Research [26830029, 24500411] Funding Source: KAKEN
The sensory circumventricular organs (CVOs) comprise the organum vasculosum of the lamina terminalis (OVLT), subfornical organ (SFO), and area postrema (AP) and lack the blood-brain barrier. The expression of Toll-like receptor 4 (TLR4) was seen at astrocytes throughout the sensory CVOs and at microglia in the AP and solitary nucleus around the central canal. The peripheral and central administration of lipopolysaccharide induced a similar pattern of nuclear translocation of STAB. A microglia inhibitor minocycline largely suppressed lipopolysaccharide-induced astrocytic nuclear translocation of STAT3 in the OVLT and AP, but its effect was less in the SFO. (C) 2014 Elsevier B.V. All rights reserved.
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