期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 287, 期 -, 页码 43-53出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2015.08.005
关键词
Experimental autoimmune encephalomyelitis; Age; Blood-brain barrier; NADPH oxidase; MMP-9; Adhesion molecules
资金
- Public Welfare & Safety Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2011-0020952]
- Korea Institute of Science and Technology [2V03600]
- National Research Council of Science & Technology (NST), Republic of Korea [2V03600] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The aim of the present study was to investigate effect of two different ages (6 weeks [6 W] vs. 6 months [6 M]) on blood-brain barrier (BBB) disruption in EAE and evaluate the expression and correlations of NADPH oxidase, MMP-9, ICAM-1, and VCAM-1 following increased age and EAE induction. Higher disease severity was observed in 6 M-EAE than 6 W-EAE. The four factors were significantly elevated and correlated in 6 M-EAE. BBB permeability increased with statistically significant interaction between age and EAE effects. We suggest strong correlations between NADPH oxidase and the other factors play important roles in increased BBB disruption and EAE susceptibility in middle-aged mice. (C) 2015 Elsevier B.V. All rights reserved.
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