期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 287, 期 -, 页码 80-87出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2015.08.016
关键词
Multiple sclerosis; Inflammation; Apoptosis; Targeted therapy
资金
- IRCCS Santa Lucia
Multiple sclerosis (MS) is a complex, multifactorial disease associated with damage to the axonal myelin sheaths and neuronal degeneration. The pathognomonic event in MS is oligodendrocyte loss accompanied by axonal damage, blood-brain barrier leakage, inflammation and infiltration of immune cells. The etiopathogenesis of MS is far from being elucidated. However, increasing evidence suggests that the inflammatory and apoptotic responses, occurring in patients either at the peripheral level or the central nervous system (CNS), can play a role. In this review, we give a comprehensive picture of general aspects of inflammation and apoptosis in MS, with special emphasis on the until now not well highlighted possible links between phenomena relevant to these aspects occurring in either the periphery or in the CNS during MS. (C) 2015 Elsevier B.V. All rights reserved.
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