期刊
JOURNAL OF NEUROIMAGING
卷 25, 期 6, 页码 931-939出版社
WILEY
DOI: 10.1111/jon.12279
关键词
Chronic inflammatory demyelinating polyneuropathy; nerve ultrasound; electrophysiology; cross-sectional area; intranerve cross-sectional area variability
资金
- BayerSchering
- BiogenIdec
- MerckSerono
- Novartis
- Sanofi-Aventis
- TEVA
BACKGROUND AND PURPOSEWe evaluated prospectively nerve ultrasound and electrophysiology as monitoring methods of intravenous immunoglobulin (IVIG) therapy in chronic inflammatory demyelinating polyneuropathy (CIDP). METHODSOverall 15 healthy subjects and 11 CIDP patients undergoing IVIG therapy were recruited in the study. All patients underwent clinical, ultrasound, and electrophysiological evaluation at the time point of first onset of symptoms (<6 weeks of symptoms) and 4, 8, and 12 months after onset. RESULTSThe intranerve cross-sectional area (CSA) variability of each nerve, but not the CSA alone, correlated with the MRC Scale score during 12-month follow-up. On the other hand, none of the electrophysiological parameters correlated with the MRC Scale Score in each of the peripheral nerves. Interestingly, in of the CIDP patients, the resolution of the conduction block correlated with the improvement in the MRC Sum score. CONCLUSIONSNerve ultrasound and in particular the intranerve CSA variability seems to be a useful method in monitoring CIDP patients. Although the sample size is small, the intranerve CSA variability seems to be more promising than neurophysiology.
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