期刊
CURRENT ALLERGY AND ASTHMA REPORTS
卷 14, 期 1, 页码 -出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11882-013-0404-6
关键词
Western diet; Autoimmune diseases; Autoimmunity; Obesity; Sodium; Inflammatory; Gut microbiome; T cell regulation
资金
- National MS Society Collaborative Research Center Award [CA1061-A-18]
- National Institutes of Health [P01 AI045757, U19 AI046130, U19 AI070352, P01 AI039671, P30-ES002109, U01 CA164337]
- National Institute of Neurological Disorders and Stroke [NS2427]
- Penates Foundation
- Nancy Taylor Foundation for Chronic Diseases, Inc.
- NATIONAL CANCER INSTITUTE [U01CA164337] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI070352, U19AI046130, U01AI102011, P01AI045757, R01AI091568, P01AI039671] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES002109] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS024247] Funding Source: NIH RePORTER
Developed societies, although having successfully reduced the burden of infectious disease, constitute an environment where metabolic, cardiovascular, and autoimmune diseases thrive. Living in westernized countries has not fundamentally changed the genetic basis on which these diseases emerge, but has strong impact on lifestyle and pathogen exposure. In particular, nutritional patterns collectively termed the Western diet, including high-fat and cholesterol, high-protein, high-sugar, and excess salt intake, as well as frequent consumption of processed and 'fast foods', promote obesity, metabolic syndrome, and cardiovascular disease. These factors have also gained high interest as possible promoters of autoimmune diseases. Underlying metabolic and immunologic mechanisms are currently being intensively explored. This review discusses the current knowledge relative to the association of Western diet with autoimmunity, and highlights the role of T cells as central players linking dietary influences to autoimmune pathology.
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