期刊
CURRENT ALLERGY AND ASTHMA REPORTS
卷 12, 期 5, 页码 448-455出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11882-012-0276-1
关键词
Cockroach; Allergen; Protease; Dendritic cell; Allergy; Airway epithelium; Protease-activated receptor; Airway hyperresponsiveness; Allergic airway inflammation; Innate immune response; Neutrophil; TNF-alpha; Alveolar macrophage; Eosinophil; Mucin; CCL20; GM-CSF; TLR; NOD; CD80; CD86
资金
- National Institutes of Health [HL75568]
Allergic asthma is on the rise in developed countries, and cockroach exposure is a major risk factor for the development of asthma. In recent years, a number of studies have investigated the importance of allergen-associated proteases in modulating allergic airway inflammation. Many of the studies have suggested the importance of allergen-associated proteases as having a direct role on airway epithelial cells and dendritic cells. In most cases, activation of the protease activated receptor (PAR)-2 has been implicated as a mechanism behind the potent allergenicity associated with cockroaches. In this review, we focus on recent evidence linking cockroach proteases to activation of a variety of cells important in allergic airway inflammation and the role of PAR-2 in this process. We will highlight recent data exploring the potential mechanisms involved in the biological effects of the allergen.
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