期刊
CURRENT ALLERGY AND ASTHMA REPORTS
卷 12, 期 5, 页码 438-447出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11882-012-0283-2
关键词
Lipocalin; Allergy; Allergen; Mammalian; Cat; Dog; Horse; Cattle; Guinea pig; Rabbit; Hamster; Mouse; Rat; Arthropod; Cross-reactivity
资金
- Ministry of Higher Education and Research of Luxembourg
Lipocalins represent the most important group of inhalant animal allergens. For some of them, three-dimensional protein structures have been resolved, but their functions are still elusive. Lipocalins generally display a low sequence identity between family members. The characterization of new lipocalin allergens has revealed however that some of them display a high sequence identity to lipocalins from another species. They constitute a new group of potentially cross-reactive molecules which, in addition to serum albumins, may contribute to allergic cross-reactions between animal dander of different species. However, the clinical relevance of cross-reactivity needs to be assessed. Further studies are needed to understand which of these animal lipocalins are the primary allergens and which are cross-reacting molecules. The use of single, well characterized allergens for diagnosis will allow the identification of the sensitizing animal, which is a prerequisite for specific immunotherapy.
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