期刊
CURRENT ALLERGY AND ASTHMA REPORTS
卷 13, 期 1, 页码 19-26出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11882-012-0313-0
关键词
Probiotics; Commensal bacteria; LAB; Microbiota; Lactobacilli; Bifidobacteria; Dendritic cells; T-cell polarization; Th1; Th2; Th17; Inflammatory bowel diseases; Allergy; Crohn's disease; Ulcerative colitis; Immune-mediated diseases; Interleukins; TLRs; MALT; GALT; IEC; Immunotherapy; Immunopathology; Autoimmunity; PRR; PAMP; Mucosal immunology
资金
- Associazione Italiana Ricerca sul Cancro (AIRC) [IG11650]
The cross-talk between the mucosa-associated immune system and microbiota is critical in mucosal tissue homeostasis as well as in protection against infectious and inflammatory diseases occurring at mucosal sites. This recent evidence has paved the way to therapeutic approaches aimed at modulating the mucosa-associated immune system using probiotics. Different strains of probiotics possess the ability to finely regulate dendritic cell (DC) activation, polarizing the subsequent T cell activity toward Th1 (e.g. Lactobacillus (Lb) acidophilus), Th2 (Lb.reuteri and Bifidobacterium bifidum) or, as more recently demonstrated, Th17 responses induced by specific strains such as Lb.rhamnosus GG and Lac23a, the latter isolated in our laboratory. Here, we review some recent advances in our understanding of probiotics effects on mucosal immunology, particularly on cells of the innate immunity such as DCs. We also highlight our own experiences in modulating DC functions by commensal bacteria and discuss the relevance of probiotics administration in the treatment of human immunopathologies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据