期刊
CURRENT ALLERGY AND ASTHMA REPORTS
卷 8, 期 5, 页码 398-403出版社
CURRENT SCIENCE INC
DOI: 10.1007/s11882-008-0077-8
关键词
-
资金
- National institutes of Health (NIH) [NO1-AR-2-2263, RO1 AR44422]
- National Institute of Arthritis, Musculoskeletal, and Skin Diseases
- NIH Clinical Research Program
Recent advances in genetics and technology have led to breakthroughs in understanding the genes that predispose individuals to autoimmune diseases. A common haplotype of the signal transducer and activator of transcription 4 (STAT4) gene has been shown to be associated with susceptibility to rheumatoid arthritis, systemic lupus erythematosus, and primary Sjogren's syndrome. STAT4 is a transcription factor that transduces interleukin-12, interleukin-23, and type I interferon cytokine signals in T cells and monocytes, leading to T-helper type I and T-helper type 17 differentiation, monocyte activation, and interferon-gamma production. Although the evidence for this association is very strong and well replicated, the exact mechanism by which polymorphisms in this gene lead to disease remains unknown. In concert with the identification of other disease-associated loci, elucidating how the variant form of STAT4 modulates immune function should lead to an improved understanding of the pathophysiology of autoimmunity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据