期刊
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
卷 6, 期 6, 页码 497-501出版社
WILEY
DOI: 10.1111/cts.12055
关键词
neurostimulation; electrical stimulation; deep brain stimulation
资金
- NIH/NCATS CTSA [TL1 RR0024152]
- NIH/NINDS [K08 NS 52252, R01 NS 70872, R01 NS 74013]
Electrical stimulation of the brain has a 2000 year history. Deep brain stimulation (DBS), one form of neurostimulation, is a functional neurosurgical approach in which a high-frequency electrical current stimulates targeted brain structures for therapeutic benefit. It is an effective treatment for certain neuropathologic movement disorders and an emerging therapy for psychiatric conditions and epilepsy. Its translational journey did not follow the typical bench-to-bedside path, but rather reversed the process. The shift from ancient and medieval folkloric remedy to accepted medical practice began with independent discoveries about electricity during the 19th century and was fostered by technological advances of the 20th. In this paper, we review that journey and discuss how the quest to expand its applications and improve outcomes is taking DBS from the bedside back to the bench.
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