期刊
CRYSTENGCOMM
卷 15, 期 1, 页码 206-212出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ce26315g
关键词
-
资金
- National Basic Research Program of China (973 Program) [2012CB933600]
- National Natural Science Foundation of China [51172260, 51121064, 51102258]
- Science and Technology Commission of Shanghai [11nm0506600, 1052nm06200]
- CAS/SAFEA International Partnership Program for Creative Research Teams
In this paper, a surfactant-free rapid microwave-assisted hydrothermal synthesis of hydroxyapatite nanosheet-assembled flower-like hierarchical nanostructures (NFHNs) is reported. The effects of the experimental conditions on the morphology and crystal phase of the product are investigated. A possible formation mechanism of hydroxyapatite NFHNs is proposed. The morphology of the product can vary from flower-like to polyhedra by adjusting the microwave heating temperature. The protein and DNA adsorption properties of the as-prepared hydroxyapatite NFHNs are studied. The loading capacities of the as-prepared hydroxyapatite NFHNs for bovine serum albumin (BSA), hemoglobin (Hb) and fish sperm DNA are determined to be 165, 164 and 112 mg g(-1), respectively. The protein release process is conducted at different pH values (pH 7.2, 5.5 and 4.8) in phosphate buffer saline (PBS), and the pH-controlled protein release behavior has been found. Thus, the as-prepared hydroxyapatite NFHNs are promising for protein drug delivery applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据