Concomitant cocrystallization on engineered surfaces

Engineered self-assembled monolayer (SAM) substrates were successfully illustrated as a high throughput polymorph screening method for cocrystals. In this study, we have obtained new polymorphs of the cocrystals of caffeine and oxalic acid (2 : 1 molar ratio). This is evidenced by the Raman spectra, which showed new peaks at 1076, 1588 and 1602 cm(-1). In addition, the XRD diffraction pattern exhibited a new peak at 30.0 degrees, further confirming the presence of new polymorphs.