Carboxylic acid-derived oxacalix[2]arene[2]pyrazine self-assembles into unprecedented diamondoid networks

A 1,3-alternate conformational oxacalix[2]arene[2]pyrazine, 1, made up of two tetrahedrally oriented -COOH functions and two upper rim pyrazinyl nitrogen atoms, self-assembles into an unprecedented six-fold interpenetrated diamondoid network via intermolecular hydrogen bond interactions. Disordered guest molecules could be included in the hydrophobic channels presented in the supramolecular aggregates.