A cocrystal is the key intermediates for the production of a new polymorph of Vorinostat

A new kinetically stable polymorph of Vorinostat has been discovered as a result of a polymorph screening, however an impurity is always formed in its preparation by crystallization. The interaction of Vorinostat with ammonia yields a new cocrystal which transforms easily through thermal desorption into the new polymorph with a high degree of purity.