期刊
CRYSTAL GROWTH & DESIGN
卷 14, 期 2, 页码 513-522出版社
AMER CHEMICAL SOC
DOI: 10.1021/cg401257w
关键词
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资金
- SB RAS [108]
- Ministry of Education and Science of the Russian Federation [14.B37.21.1093]
- Praesidium of the RAS [24.38]
- Department of Chemistry and Materials Sciences of the RAS [5.6.4]
In the present work, four solvates of furosemide with tetrahydrofuran S(THF), 1,4-dioxane S(DIOX), N,N-dimethylformamide S(DMF), and dimethylsulfoxide S(DMSO) were crystallized, the crystal structures were solved for S(THF), S(DIOX), and S(DMF). The existence of S(THF) and S(DMSO) was not reported before; for the previously known S(DIOX) and S(DMF), the crystal structures remained unsolved. The detailed structural analysis of furosemide containing crystal structures showed that the molecule of furosemide has a high conformational lability because of the rotations of the sulfamoyl and furanylmethylamino fragments. Some of the furosemide conformations were shown to be stabilized by the intramolecular N-H center dot center dot center dot Cl hydrogen bond. Desolvation of the four solvates was studied by TG and X-ray diffraction and was shown to give different products depending on the precursor and particle size: the desolvation of powder of S(THF) and the large crystals of S(THF), S(DIOX), and S(DMF) gives Form-III of furosemide, whereas powders of S(DIOX), S(DMF), and S(DMSO) give Form-I.
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