期刊
CRYSTAL GROWTH & DESIGN
卷 12, 期 4, 页码 2122-2126出版社
AMER CHEMICAL SOC
DOI: 10.1021/cg300152p
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资金
- National Institutes of Health [GM072737]
Crystal structures for the commercial monohydrate form and an anhydrate form of dasatinib, an oral anticancer agent, are presented along with characterization by Raman spectroscopy, powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis. Solubility measurements conducted in water reveal that the anhydrate has dramatically improved solubility compared to the commercial hydrate form. Finally, dasatinib is a rare example of a promiscuous solvate former, and the basis for this behavior can now be understood by examining the poor packing efficiency in the unsolvated form.
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