期刊
CRYSTAL GROWTH & DESIGN
卷 12, 期 3, 页码 1683-1692出版社
AMER CHEMICAL SOC
DOI: 10.1021/cg300019f
关键词
-
资金
- University of Cape Town
- North-West University
- National Research Foundation of South Africa
Three non-isostructural solvates of the antibacterial dapsone (DDS) containing dichloromethane [DDS center dot 0.5(DCM)], 1,4-dioxane [DDS center dot DXN], and tetrahydrofuran [DDS center dot THF] were prepared and characterized by X-ray diffraction (XRD) and thermal analysis, the latter including hot stage microscopy (HSM), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). In addition, their thermal desolvation was investigated by isothermal kinetic studies which indicated the A2 model as the best fit for desolvation of the DCM and DXN solvates, while the R2 model was indicated for the THE solvate. Activation energies for desolvation of these new species were in the range 141-173 kJ mol(-1). Attempts were made to reconcile the kinetic models with the observed HSM desolvation behavior and the modes of solvent inclusion within the solvate crystals determined by XRD (viz, isolated sites for the DCM solvate and channel-type for the others).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据