Cocrystal Formation from Solvent Mixtures

Solvent mixtures can be used to thermodynamically suppress solvate formation as a competing reaction in solution-based cocrystallization experiments. This has been demonstrated successfully for the cocrystallization of carbamazepine and saccharin in the presence of up to nine different solvate-forming solvents and was further tested by cocrystallization experiments with 18 other known cocrystal formers of carbamazepine. It was found that the chances of success of this approach increase with the number of solvents in the mixture. It was additionally observed that solvent mixtures can be used to level out the solubility differences between different compounds.