期刊
JOURNAL OF NATURAL PRODUCTS
卷 78, 期 4, 页码 811-821出版社
AMER CHEMICAL SOC
DOI: 10.1021/np501057f
关键词
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资金
- National Natural Science Foundation of China [31160374]
- Youth Innovation Promotion Association, CAS [2015323]
- National Key Scientific Instrument Development Projects of China [2011YQ12003506]
- Scientific and Technological Planning Project of Guizhou [QKH-ZY[2013] 3015]
Fourteen new limonoids, munronins A-N (1-14), and eight known limonoids (15-22) were isolated from the whole plants of Munronia henryi. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry, and the structure of 8 was confirmed by single-crystal X-ray diffraction analysis. Compound 1 represents the first limonoid found with a novel 7-oxabicyclo[2.2.1]heptane moiety produced by incorporating C-11 and C-14 via an oxygen atom. All compounds were evaluated for their anti-tobacco mosaic virus (TMV) activity and in vitro cytotoxicity against the human cancer HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Among them, compounds 2, 8, 9, 10, 11, 12, 18, and 20 showed significant anti-TMV activity, with IC50 values in the range 19.6-44.4 mu g/mL. Compounds 1 and 18 exhibited cytotoxic effects for all five cancer cell lines, with IC50 values between 0.4 and 4.8 mu M.
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