期刊
JOURNAL OF NATURAL PRODUCTS
卷 78, 期 9, 页码 2310-2314出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00575
关键词
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资金
- National Natural Science Foundation of China [41130858, 41322037, 81172977, 41176121]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
Three new azaphilone derivatives, pinophilins D-F (1-3), and one new diphenyl ether derivative, hydroxypenicillide (10), together with nine known compounds (4-9, 11-13), were isolated from the gorgonian-derived fungus Penicillium pinophilum XS-20090E18. Their structures including absolute configurations were determined by spectroscopic data, chemical conversions, the ECD exciton chirality method, and ECD calculations. Compounds 10-13 exhibited inhibitory activity against the larval settlement of the barnacle Balanus amp hitrite at nontoxic concentrations. Compounds 10 and 11 showed cytotoxicity against Hep-2, RD, and HeLa cell lines.
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