期刊
JOURNAL OF NATURAL PRODUCTS
卷 78, 期 5, 页码 1179-1183出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00092
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资金
- Strategic International Collaborative Research Program (SICORP)
- JST
- Japan Advanced Plant Science Network
The discovery of bioactive natural compounds containing sulfur, which is crucial for inhibitory activity against angiotensin-converting enzyme (ACE), is a challenging task in metabolomics. Herein, a new S-containing metabolite, asparaptine (1), was discovered in the spears of Asparagus officinalis by targeted metabolomics using mass spectrometry for S-containing metabolites. The contribution ratio (2.2%) to the IC50 value in the crude extract showed that asparaptine (1) is a new ACE inhibitor.
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