期刊
JOURNAL OF NATURAL PRODUCTS
卷 78, 期 1, 页码 34-42出版社
AMER CHEMICAL SOC
DOI: 10.1021/np5005856
关键词
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资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2010-0010549]
- BK 21 Plus Program of the Ministry of Education, Science and Technology, Korea
- National Research Foundation of Korea [2010-0010549] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
As part of an ongoing search for new antidiabetic agents from medicinal plants, three new (2, 4, and 5) and two known selaginellin derivatives (1 and 3) were isolated from a methanol extract of Selaginella tamariscina. The structures of the new compounds were determined by spectroscopic data analysis. All isolates showed strong glucose uptake stimulatory effects in 3T3-L1 adipocyte cells at a concentration of 5 mu M. Furthermore, these compounds were found to possess inhibitory effects on PTP1B enzyme activity with IC50 values ranging from 4.6 +/- 0.1 to 21.6 +/- 1.5 mu M. Compound 2 showed the greatest potency, with an IC50 value of 4.6 +/- 0.1 mu M, when compared with the positive control (ursolic acid, IC50 = 3.5 +/- 0.1 mu M). Therefore, these selaginellin derivatives may have value as new lead compounds for the development of agents against type 2 diabetes.
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