期刊
JOURNAL OF NATURAL PRODUCTS
卷 78, 期 11, 页码 2642-2647出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00576
关键词
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资金
- European Community's Seventh Framework Programme [289285]
- Regione Lombardia, University and Research [30190679]
- Regione Lombardia and Italian Ministry of Education [30190679]
We identified an Actinoallomurus strain producing NAI-107, a chlorinated lantibiotic effective against multidrug-resistant Gram-positive pathogens and previously reported from the distantly related genus Microbispora. Inclusion of KBr in the production medium of either the Actinoallomurus or the Microbispora producer readily afforded brominated variants of NAI-107, which were designated as NAI-108. The other post-translational modifications naturally occurring in this lantibiotic family (i.e., hydroxylation of Pro-14 and C-terminal decarboxylation) were unaffected by the presence of a brominated tryptophan. In addition to being the first example of a bromine-containing lantibiotic, NAI-108 displayed a small but consistent improvement in antibacterial activity against all tested strains. The brominated lantibiotic maintained the same rapid bactericidal activity as NAI-107 but at reduced concentrations, consistent with its increased potency and with the role played by the hydrophobicity of the first lanthionine ring. NAI-108 thus represents an interesting addition to a promising family of potent and effective lantibiotics.
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