期刊
JOURNAL OF NATURAL PRODUCTS
卷 78, 期 4, 页码 658-665出版社
AMER CHEMICAL SOC
DOI: 10.1021/np5008203
关键词
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资金
- NIH [RC2 AT005899]
- United States Pharmacopeial Convention through the USP Global Research Program
This report describes a fragment-based approach to the examination of Congeneric organic compounds by NMR spectroscopy. The method combines the classic interpretation of 1D- and 2D-NMR data sets with contemporary computer-assisted NMR analysis., Characteristic NMR profiles of key structural motifs were generated by H-1 iterative full spin analysis and then joined together as building blocks to recreate the H-1 NMR spectra of increasingly complex molecules. To illustrate, the methodology described, a comprehensive analysis of steviol (1) seven steviol glycosides (2-8) and two structurally related isosteviol compounds (9, 10) was carried out The study also assessed the potential impact of this method on relevant aspects of natural product research including structural Verification, chemical dereplication, and mixture analysis.
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