期刊
JOURNAL OF NATURAL PRODUCTS
卷 78, 期 11, 页码 2684-2690出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00631
关键词
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资金
- Fundacao para a Ciencia e a Tecnologia (FCT), Portugal [PTDC/QEQMED/0905/2012, RECl/QEQQIN7/0189/2012, SFRH/BD/72915/2010, SFRH/BPD/78854/2011]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/72915/2010] Funding Source: FCT
Euphowelwitschines A (1) and B (2), isolated from a methanolic extract of Euphorbia welwitschii, exhibit a rare combination of structural features in having a 5/8/8 fused-ring system and a 12,15-ether bridge. Moreover, the isolation of the additional new compounds welwitschene (3) and epoxywelwitschene (4) has provided insights into the biogenetic pathway of 12,17-cyclojatrophanes. The structures of 1-4 were determined by spectroscopic methods inclusive of 1D and 2D NMR experiments and X-ray crystallography for compounds 1 and 2. Preliminary information on the selective antiproliferative activity of compounds 1-4 is also described.
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