期刊
JOURNAL OF NATURAL PRODUCTS
卷 78, 期 9, 页码 2249-2254出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00469
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资金
- Korea Institute of Oriental Medicine [K15270]
- National Research Council of Science & Technology (NST), Republic of Korea [K15270] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Three new phenolic biphenyl derivatives (1-3) and one new lignan glycoside (4) were isolated from the leaves and twigs of Osteomeles schwerinae. The structures of the new compounds were established by spectroscopic data interpretation. The inhibitory effects of 1-4 on rat lens aldose reductase in vitro were examined, and compounds 1-3 markedly inhibited the enzyme with IC50 values of 3.8 to 13.8 mu M. In addition, the effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in zebrafish larvae were investigated. Compound 1 was the most effective in reducing HG-induced dilation of hyaloid-retinal vessels.
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