期刊
JOURNAL OF NATURAL PRODUCTS
卷 78, 期 10, 页码 2405-2410出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00487
关键词
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资金
- National Natural Science Foundation of China [81422045, U1405223, 21272195]
- China's 1000 Young Talents Program
- Science and Technology Plan Project of Xiamen [3502Z20133010]
- Fundamental Research Funds for Central Universities of China [2011121030, 2013121032]
Aspertetranones A-D (1-4), four new highly oxygenated putative rearranged triketide-sesquiterpenoid meroterpenes, were isolated from the marine algal-associated fungus Aspergillus sp. ZL0-1b14. On the basis of a comprehensive spectroscopic analysis, the planar structures of aspertetranones were determined to possess an unusual skeleton in the terpenoid part. The relative and absolute configurations of the aspertetranones were assigned on the basis of NOESY analysis, X-ray crystallography, and circular dichroism spectroscopy. Compounds 1-4 were evaluated for anti-inflammatory activity in LPS-stimulated RAW264.7 macrophages. Aspertetranone D exhibited an inhibitory effect against IL-6 production with 69% inhibition at 40 mu M.
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